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Shareef,
M.M., Kokkinakis, D.M. and Ahmed,
M.M. Potential Use of
MDA-7
as a Biological Adjuvant for Radiation Therapy.Cancer
Biol Ther. 2004
Aug 15;3(8). [Epub ahead of print]
Arnold,
S.M., Regine, W.F., Ahmed, M.M.,
Valentino, J., Spring, P., Kudrimoti, M., Kenady, D., Desimone, P. and
Mohiuddin, M. Low-dose
fractionated radiation as a
chemopotentiator of neoadjuvant paclitaxel and carboplatin for locally
advanced squamous cell carcinoma of the head and neck: results of a new
treatment paradigm.
Int J Radiat Oncol
Biol Phys. 2004 Apr 1;58(5):1411-7.
Ranga, R.S., Girija,
R., Nur-e-Alam, M., Sathishkumar, S., Akbarsha, M.A., Thirugnanam, S.,
Rohr, J., Ahmed, M.M.
and Chendil, D.Rasagenthi
lehyam (RL) a novel complementary and alternative medicine for prostate
cancer.Cancer
Chemother
Pharmacol. 2004 Jul;54(1):7-15. Epub 2004 Mar 24.
Chendil,
D., Ranga, R.S., Meigooni, D., Sathishkumar, S., Ahmed., M.M.
Curcumin confers radiosensitizing effect in prostate cancer cell line
PC-3. Oncogene. 2004 Feb
26;23(8):1599-607.
Ahmed,
M. M. Regulation of
radiation-induced
apoptosis by early growth response-1 gene in solid tumors. Current
Cancer
Drug Targets, 4: 43-52, 2004.
Spring,
P.M., Arnold, S.M., Dimova, N., Shajahan, S., Brown, B.,
Dey, S.,
Lele, S., Valentino, J., Jones, R., Mohiuddin, M. and Ahmed,
M.M.
Low Dose Fractionated Radiation Potentiates the Effects of Taxotere in
Nude
Mice Xenografts of squamous cell carcinoma
of head
and neck. Cell
Cycle. 2004 Apr;3(4):479-85. Epub 2004 Apr 01.
Rushing,
R. S., Shajahan, S., Chendil, D., Wilder, J. L.,
Pulliam, J., Lee, E. Y., Ueland, F. R., van Nagell, J. R., Ahmed,
M. M.,
and Lele, S. M. Uterine sarcomas express KIT protein but lack
mutation(s) in
exon 11 or 17 of c-KIT. Gynecologic Oncology, 91: 9-14, 2003.
Kokkinakis,
D.M., Ahmed, M.M., Chendil, D., Moschel,
R.C. and Pegg, A.E. Sensitization of pancreatic tumor
xenografts to carmustine and temozolomide by inactivation
of
their O6-Methylguanine-DNA methyltransferase with
O6-benzylguanine or O6-benzyl-2-deoxyguanosine. Clinical Cancer Res,
9: 3801-3807,
2003.
Halepota,
M., Mohiuddin, M., Desimone, P. and Ahmed, M.M. Durable
local
responses with subtherapeutic doses of concurrent radiation and
gemcitabine in
a patient with refractory Hodgkin?s disease. Clinical
Advances in
Hematology & Oncology, 1 (7): 413-415, 2003.
Dey, S.,
Spring, P. M., Arnold, S., Valentino, J., Chendil, D., Regine, W.
F.,
Mohiuddin, M., and Ahmed, M. M. Low dose fractionated radiation
potentiates the effects of paclitaxel in wild-type and mutant p53 head
and neck
tumor cell lines. Clinical Cancer Res, 9, 1557-1565,
2003.
Mayhew,
C.N., Mampuru, L.J., Chendil, D., Ahmed, M.M., Phillips, J.D.,
Greenberg, R.N., Elford, H.L. and Gallicchio, V.S. Supression of
retrovirus-induced immunodeficiency disease (murine AIDS) by trimidox
and
didox: novel ribonucleotide reductase inhibitors with less bone marrow
toxicity
than hydroxyurea. Antiviral Res., 56: 167-181, 2002.
Alcock,
R. A., Dey, S., Chendil, D., Inayat, M. S., Mohiuddin, M., Hartman, G.,
Chatfield,
L. K., Gallicchio, V. S., and Ahmed, M. M. Farnesyltransferase
inhibitor
(L-744,832) restores TGF-beta type II receptor expression and enhances
radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA
PaCa-2. Oncogene, 21: 7883-7890, 2002.
Inayat,
M. S., Chendil, D., Mohiuddin, M., Elford, H. L., Gallicchio, V. S.,
and Ahmed,
M. M. Didox A Novel Ribonucleotide Reductase Inhibitor overcomes
bcl-2
mediated radiation resistance in prostate cancer cell line PC-3. Cancer
Biol
Ther, 1: 539-545, 2002 (see
editorial commentary).
Siddiqua,
A., Chendil, D., Rowland, R., Meigooni, A.S., St Clair, W.B.,
Mohiuddin, M. and Ahmed, M.M. Increased expression of PSA mRNA
during the
brachytherapy
procedure in peripheral blood of patients with prostate cancer. Urology
60 (2): 270-275, 2002.
Mohiuddin,
M., Chendil, D., Dey, D., Alcock, R.A., Regine, W., Mohiuddin, M. and Ahmed,
M.M. Influence of p53 status on radiation and 5-Flourouracil
synergy in
pancreatic cancer cells. Anticancer Research 22 (2): 825-830,
2002.
Ahmed,
M.M.,
Satishkumar, S., Fruitwala, S.M., Venkatasubbarao, K., Meigooni, A.S.
and
Mohiuddin, M. Spatially fractionated (GRID) radiation: TNF-a mediated therapeutic gain in
enhanced cell
killing of radioresistant tumor cells. Technology in Cancer
Research
Treatment 1 (2):141-147, 2002.
Chendil,
D., Das, A., Dey, S., Mohiuddin, M., and Ahmed, M.M. Par-4, a
pro-apoptotic gene, inhibits NFkB activity resulting in the
repression of radiation-induced bcl-2 expression leading to induction
of
radiosensitivity in human prostate cancer cells PC-3. Cancer
Biology and
Therapy 1 (2) 152-160, 2002.
Ahmed,
M.M., Alcock, R.A., Chendil,
D., Dey,
S., Das, A., Venkatasubbarao, K., Mohiuddin, M., Sun, L., Strodel W.E.
and
Freeman, J.W. Restoration of TGF-b
signaling enhances
radiosensitivity by altering the bcl-2: bax ratio in the p53 mutant
pancreatic
cancer cell line MIA PaCa-2. J Biological Chemistry , 277 (3):
2234-2246,
2002..
Ozkan, L.,
Egeli, U., Tunca, B., Aydemit, N., Cecener, G., Ergul, E.,
Akpinar, G., Ergul, E., Cimen, C., Ozuysal, S., Kahraman-Cetintas, S.,
Engin,
K. and Ahmed, M.M. Investigation of genotoxic effect of
Taxol plus
radiation on mice bone marrow cells. Teratogenesis,
Carcinogenesis,
and Mutagenesis 22: 1-11, 2002.
Ahmed, M.M., Chendil, D., Lele,
S., Venkatasubbarao, K., Dey, S., Ritter, M., Rowland, R. and
Mohiuddin,
M. Early growth response-1 gene : potential radiation response
gene
marker in prostate cancer. Am J of Clin Oncol (CCT) 24
(5):
500-505, 2001.
Ozkan,
L., Ozuysal, S., Egeli, U., Adim, S.B., Tunca, B., Aydemit, N.,
Cecener, G.,
Ergul, E., Akpinar, G., Cimen, C., Engin, K. and Ahmed, M.M.
Effects of taxol plus radiation on the apoptotic and mitotic indices of
mouse
intestinal crypt cells. Journal of Cancer Res and Clin Oncol 127:
127-433, 2001.
Das,
A., Chendil, D., Dey, S., Mohiuddin, M., Mohiuddin, M.,
Milbrandt, J.,
Rangnekar, V.M and Ahmed, M.M. Ionizing radiation
down-regulates p53
protein in primary Egr-1-/- mouse embryonic fibroblast cells
causing
enhanced resistance to apoptosis. J Biological Chemistry
276
(5):3279-3286, 2001.
Chendil,
D., Oakes, R., Alcock, R., Patel, N., Mayhew, C., Gallicchio, V.S.,
Mohiuddin,
M. and Ahmed, M.M. Fractionated radiation enhances
radiosensitization
effect of paclitaxel in colorectal tumor cells with mutant p53
phenotype. Cancer
89:1893-1900, 2000
Fralix,
K.D, Ahmed, M.M., Mattingly, C., Swiderski, C., McGrath,
P.,
Venkatasubbarao, K., Kamada, N., Mohiuddin, M., Strodel, W.E. and
Freeman,
J.W. Characterization of newly established human pancreatic
carcinoma
cell line, UK Pan-1. Cancer 88:2010-2021, 2000.
Venkatasubbarao,
K., Ahmed, M.M., Mohiuddin, M., Swiderski, S., Lee,
E.,
Gower, W. R. Jr., Salhab, K.F., McGrath,
P., Strodel,
W. and Freeman, J.W. Differential Expression of
Transforming Growth
Factor b Receptors in Human Pancreatic
Adenocarcinoma. Anticancer
Research 20:43-52, 2000.
Mohiuddin,
M., Fujita, M., Regine, W.F., Megooni, A.S.,
Ibbott, G.S. and Ahmed, M.M. High dose spatially
fractionated
radiation (GRID): A new paradigm in the management of advanced cancers.
Int.
J. Radiat. Oncol. Biol. Phy , 44 (5): 1999.
Qui,
G., Ahmed, M.M., Sells, S.F., Cookson, M.S., Mohiuddin, M.,
Weinstein,
M.H. and Rangnekar, V.M. Mutually exclusive expression pattern of
Bcl-2
and Par-4 in human prostate tumors consistent with down regulation of
Bcl-2 by
Par-4. Oncogene, 18:623-631,1999.
Venkatasubbarao,
K., Ahmed, M.M., Swiderski, C., Harp, C., Lee, E., McGrath,
P.,
Mohiuddin, M., Strodel, W., and Freeman, J.W. Novel mutations in
the
polyadenine tract of the transforming growth factor-b type II receptor gene are found
in a
subpopulation of human pancreatic adenocarcinomas. Genes,
Chromosomes
& Cancer 22:138-144, 1998.
Ahmed,
M.M.,
Sells, S., Venkatasubbarao, K., Fruitwala, S.,
Muthukkumar,
S., Harp, C., Mohiuddin, M., and Rangnekar, V. Ionizing
radiation-inducible apoptosis in the absence of p53 linked to
transcription
factor EGR-1. J Biological Chemistry 272(52):
33056-33061,
1997.
Kokkinakis,
D.M., Ahmed, M.M., Delgado, R., Fruitwala, M.A., Mohiuddin, M.
and
Albores-Saavedra, J. Role of O6-methyl guanine-DNA
methyltransferase in
the resistance of pancreatic tumors to DNA alkylating agents. Cancer
Research 57 (23):5360-5368, 1997
Mohiuddin,
M. and Ahmed, M.M. Critical issues in the evolving
management of
rectal cancer. Seminars Oncol 24 (6):732-744,
1997.
Ahmed,
M.M.,Venkatasubbarao,
K., Fruitwala, S., Muthukkumar, S., Wood, Jr.P., Sells,
S.F.,
Mohiuddin, M., and Rangnekar, V.M. EGR-1 induction is
required for
maximal radio sensitivity in A375-C6 melanoma cells. J
Biological Chemistry 271 (46): 29231-29237, 1996.
Lee,
J.H., Lee, S.K., Yang, M.H., Ahmed, M.M., Mohiuddin, M, Lee,
E.Y.
Expression and mutation of H-ras in uterine cervical cancer. Gynecologic
Oncology 62 : 49-54, 1996.
Mohiuddin,
M., Ahmed, M.M., Venkatasubbarao, K. c-Ki-ras mutations
in peripheral
blood of pancreatic cancer patients: A marker for early tumor
metastasis. Int. J. Radiat. Oncol. Biol. Phys
34
(1): 161-166, 1995.
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